Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion

• Main Authors: Mahmoud El Azzouny (Author), Melissa J. Longacre (Author), Israr-ul H. Ansari (Author), Robert T. Kennedy (Author), Charles F. Burant (Author), Michael J. MacDonald (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2016-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Objective: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short ch...