The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington's disease in rats: shifting paradigms in Huntington's disease treatment

• Автори: Hanaa Wanas (Автор), Mostafa Adel Rabie (Автор), Basma Emad Aboulhoda (Автор), Nagwa Mahmoud Ramadan (Автор), Sahar Abdelwahab (Автор), Sara Sayed Kadry Abdallah (Автор), Eid Nassar Ali (Автор), Leyan Nasruddeen Khayruddeen (Автор), Yasir Hassan Elhassan (Автор), Hadel Mahroos Alghabban (Автор), Shaimaa Mohamed Abdelsalam (Автор), Amira Karam Khalifa (Автор)
• Формат: Книга
• Опубліковано: SpringerOpen, 2024-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background The exact pathogenesis of Huntington's disease (HD) remains unclear. However, mitochondrial dysfunction and oxidative stress are supposed to play a significant role. The objective of this study was to examine the possible neuroprotective effect of Lisinopril (Lisino) in a 3-...