Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model

• Main Authors: Wiam El Kheir (Author), Anaïs Dumais (Author), Maude Beaudoin (Author), Bernard Marcos (Author), Nick Virgilio (Author), Benoit Paquette (Author), Nathalie Faucheux (Author), Marc-Antoine Lauzon (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Extensive investigation has been undertaken regarding drug delivery systems for the management of glioblastoma multiforme (GBM). The infiltrative behavior of GBM cells within the brain tissue is primarily attributed to their heterogeneity, the movement of interstitial fluid (IFF), and...