G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

• Main Authors: Jiaping Chen (Author), Rong Zhao (Author), Yangwei Wang (Author), Han Xiao (Author), Wei Lin (Author), Mingxin Diao (Author), Shiwen He (Author), Peiyuan Mei (Author), Yongde Liao (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that estrogen receptors (ERs) contribute to the develop...