Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer

• Main Authors: Arturo Valle-Mendiola (Author), Adriana Gutiérrez-Hoya (Author), María del Carmen Lagunas-Cruz (Author), Benny Weiss-Steider (Author), Isabel Soto-Cruz (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-2 receptor (IL-2R) signalling is critical for normal lymphocyte proliferation, but its role in cervical cancer is not fully understood. The receptor is composed of three chains: IL-2α, IL-2β, and IL-2γ. Intracellular signalling is initiated by ligand-induced heterodimerization of the IL-2β and IL...