Targeting protein-protein interaction for immunomodulation: A sunflower trypsin inhibitor analog peptidomimetic suppresses RA progression in CIA model

• Main Authors: Achyut Dahal (Author), Pravin Parajuli (Author), Sitanshu S. Singh (Author), Leeza Shrestha (Author), Jafrin Jobayer Sonju (Author), Prajesh Shrestha (Author), Ioulia Chatzistamou (Author), Seetharama Jois (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein-protein interactions (PPI) of co-stimulatory molecules CD2-CD58 are important in the early stage of an immune response, and increased expression of these co-stimulatory molecules is observed in the synovial region of joints in rheumatoid arthritis (RA) patients. A CD2 epitope region that bin...