A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

• Main Authors: Justin B Lee (Author), Kaixin Zhang (Author), Yuen Yi C Tam (Author), Joslyn Quick (Author), Ying K Tam (Author), Paulo JC Lin (Author), Sam Chen (Author), Yan Liu (Author), Jayaprakash K Nair (Author), Ivan Zlatev (Author), Kallanthottathil G Rajeev (Author), Muthiah Manoharan (Author), Paul S Rennie (Author), Pieter R Cullis (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression of the messenger RNA encoding the androgen rece...