DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

• Main Authors: Bingjiang Han (Author), Jiajun Xu (Author), Xiaowen Shi (Author), Zhanxiong Zheng (Author), Fengjie Shi (Author), Fenfen Jiang (Author), Jibo Han (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy. DL-3-n-butylphthalide (NBP), a neuroprotective agent, also has potent cardioprotective effects. In this study, the p...