Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

• Main Authors: Houlston Richard S (Author), Tomlinson Ian PM (Author), Järvinen Heikki (Author), Mecklin Jukka-Pekka (Author), Li Yilong (Author), Tuupanen Sari (Author), Niittymäki Iina (Author), Karhu Auli (Author), Aaltonen Lauri A (Author)
• Format: Book
• Published: BMC, 2011-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Common single-nucleotide polymorphisms (SNPs) in ten chromosomal loci have been shown to predispose to colorectal cancer (CRC) in genome-wide association studies. A plausible biological mechanism of CRC susceptibility associated with...