The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells

• Principais autores: Maria Narożna (Autor), Violetta Krajka-Kuźniak (Autor), Barbara Bednarczyk-Cwynar (Autor), Robert Kleszcz (Autor), Wanda Baer-Dubowska (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Nrf2 and NF-κB play a key role in inflammation-driven cancers. Conjugation of anti-inflammatory drugs with oleanolic acid oxime (OAO) may enhance their therapeutic potential as a result of downregulation of these pathways. Novel OAO derivatives conjugated with indomethacin (IND) were synthesized, an...