Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models

• Main Authors: Fawad Ali Shah (Author), Lina Al Kury (Author), Tao Li (Author), Alam Zeb (Author), Phil Ok Koh (Author), Fang Liu (Author), Qiang Zhou (Author), Ishtiaq Hussain (Author), Arif Ullah Khan (Author), Yuhua Jiang (Author), Shupeng Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss and ionic imbalance to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. These initial events are fol...