Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity

Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in tumour growth and angiogenesis. A novel series of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids have...

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Main Authors: Mai A. E. Mourad (Author), Ayman Abo Elmaaty (Author), Islam Zaki (Author), Ahmed A. E. Mourad (Author), Amal Hofni (Author), Ahmed E. Khodir (Author), Esam M. Aboubakr (Author), Ahmed Elkamhawy (Author), Eun Joo Roh (Author), Ahmed A. Al-Karmalawy (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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