Drosophila melanogaster as a function-based high-throughput screening model for antinephrolithiasis agents in kidney stone patients

• Main Authors: Sohrab N. Ali (Author), Thamara K. Dayarathna (Author), Aymon N. Ali (Author), Tijani Osumah (Author), Mohamed Ahmed (Author), Tyler T. Cooper (Author), Nicholas E. Power (Author), Dongxing Zhang (Author), Dajung Kim (Author), Rachel Kim (Author), Andre St. Amant (Author), Jinqiang Hou (Author), Thomas Tailly (Author), Jun Yang (Author), Len Luyt (Author), Paul A. Spagnuolo (Author), Jeremy P. Burton (Author), Hassan Razvi (Author), Hon S. Leong (Author)
• Format: Book
• Published: The Company of Biologists, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kidney stone disease involves the aggregation of stone-forming salts consequent to solute supersaturation in urine. The development of novel therapeutic agents for this predominantly metabolic and biochemical disorder have been hampered by the lack of a practical pre-clinical model amenable to drug...