Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids

• Prif Awduron: Andrea Angeli (Awdur), Linda J. Urbański (Awdur), Vesa P. Hytönen (Awdur), Seppo Parkkila (Awdur), Claudiu T. Supuran (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

We report the first activation study of the β-class carbonic anhydrase (CA, EC 4.2.1.1) encoded in the genome of the protozoan pathogen Trichomonas vaginalis, TvaCA1. Among 24 amino acid and amine activators investigated, derivatives incorporating a second carboxylic moiety, such as L-Asp, L- and D-...