Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor

• Main Authors: Michel Baudry (Author), Yubin Wang (Author), Xiaoning Bi (Author), Yun Lyna Luo (Author), Zhijun Wang (Author), Zeechan Kamal (Author), Alexander Shirokov (Author), Ed Sullivan (Author), Dennis Lagasca (Author), Hany Khalil (Author), Gary Lee (Author), Kathy Fosnaugh (Author), Philippe Bey (Author), Shujaath Mehdi (Author), Greg Coulter (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotective and calpain‐1 deletion exacerbates neuronal injury....