Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation

• Hoofdauteurs: Filippo Caraci (Auteur), Sara Merlo (Auteur), Filippo Drago (Auteur), Giuseppe Caruso (Auteur), Carmela Parenti (Auteur), Maria Angela Sortino (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Different types of pain can evolve toward a chronic condition characterized by hyperalgesia and allodynia, with an abnormal response to normal or even innocuous stimuli, respectively. A key role in endogenous analgesia is recognized to descending noradrenergic pathways that originate from the locus...