A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of Toll-like receptor activation in irritable bowel syndrome

• Main Authors: Gerard eClarke (Author), Declan P McKernan (Author), Gabor eGaszner (Author), Eamonn M Quigley (Author), John F Cryan (Author), Timothy G Dinan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised along the kynurenine pathway leading to the produ...