Chemical Analysis and Molecular Modelling of Cyclodextrin-Formulated Propofol and Its Sodium Salt to Improve Drug Solubility, Stability and Pharmacokinetics (Cytogenotoxicity)

• Hoofdauteurs: Benedikt Wilhelms (Auteur), Jens Broscheit (Auteur), Sergey Shityakov (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Propofol is a widely used general anesthetic in clinical practice, but its use is limited by its water-insoluble nature and associated pharmacokinetic and pharmacodynamic limitations. Therefore, researchers have been searching for alternative formulations to lipid emulsion to address the remaining s...