Agmatine Alleviates Epileptic Seizures and Hippocampal Neuronal Damage by Inhibiting Gasdermin D-Mediated Pyroptosis

• Main Authors: Xueying Li (Author), Jiahe Lin (Author), Yingjie Hua (Author), Jiaoni Gong (Author), Siqi Ding (Author), Yanru Du (Author), Xinshi Wang (Author), Rongyuan Zheng (Author), Huiqin Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Epilepsy is a common neurological disease, and neuroinflammation is one of the main contributors to epileptogenesis. Pyroptosis is a type of pro-inflammatory cell death that is related to epilepsy. Agmatine, has anti-inflammatory properties and exerts neuroprotective effects against seiz...