Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

• Main Authors: Colin N. Young (Author), Donald A. Morgan (Author), Scott D. Butler (Author), Kamal Rahmouni (Author), Susan B. Gurley (Author), Thomas M. Coffman (Author), Allyn L. Mark (Author), Robin L. Davisson (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Elevations in brain angiotensin-II cause increased energy expenditure and a lean phenotype. Interestingly, the metabolic effects of increased brain angiotensin-II mimic the actions of leptin, suggesting an interaction between the two systems. Here we demonstrate that angiotensin-type 1a r...