Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits

• Main Authors: Judith Estrada-Meza (Author), Jasmine Videlo (Author), Clara Bron (Author), Adeline Duchampt (Author), Cécile Saint-Béat (Author), Mickael Zergane (Author), Marine Silva (Author), Fabienne Rajas (Author), Sebastien G. Bouret (Author), Gilles Mithieux (Author), Amandine Gautier-Stein (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Intestinal gluconeogenesis (IGN) regulates adult energy homeostasis in part by controlling the same hypothalamic targets as leptin. In neonates, leptin exhibits a neonatal surge controlling axonal outgrowth between the different hypothalamic nuclei involved in feeding circuits and autonom...