Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway

• Main Authors: Yuan Li (Author), Ling Chen (Author), Da Zheng (Author), Jian-Xia Liu (Author), Chao Liu (Author), Shao-Hua Qi (Author), Peng-Chao Hu (Author), Xiao-Fei Yang (Author), Jia-Wei Min (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neonatal hypoxic-ischemic encephalopathy (HIE) is considered a major cause of death and long-term neurological injury in newborns. Studies have demonstrated that oxidative stress and apoptosis play a major role in the progression of neonatal HIE. Echinocystic acid (EA), a natural plant extract, show...