IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with Sjögren's syndrome

• Main Authors: A. Alunno (Author), O. Bistoni (Author), E. Bartoloni Bocci (Author), S. Caterbi (Author), B. Bigerna (Author), A. Pucciarini (Author), A. Tabarrini (Author), R. Mannucci (Author), D. Beghelli (Author), B. Falini (Author), R. Gerli (Author)
• Format: Book
• Published: PAGEPress Publications, 2013-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A small CD3+ T-cell population, that lacks both CD4 and CD8 molecules, defined as double negative (DN), is expanded in the peripheral blood of patients with systemic lupus erythematosus, produces IL-17 and accumulates in the kidney during lupus nephritis. Since IL-17 production is enhanced in saliva...