Three-dimensional analysis of perineural invasion in extrahepatic cholangiocarcinoma using tissue clearing

• Main Authors: Hirokazu Ogasawara (Author), Tadashi Yoshizawa (Author), Kiyoko Oshima (Author), Kenta Ogasawara (Author), Shunsuke Kubota (Author), Shintaro Goto (Author), Satoko Morohashi (Author), Taiichi Wakiya (Author), Norihisa Kimura (Author), Keinosuke Ishido (Author), Hiroshi Kijima (Author), Kenichi Hakamada (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Perineural invasion (PNI) is a characteristic invasion pattern of distal cholangiocarcinoma (DCC). Conventional histopathologic examination is a challenging approach to analyze the spatial relationship between cancer and neural tissue in full-thickness bile duct specimens. Therefore, we used a tissu...