Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation

• Main Authors: Qiu-Meng Xie (Author), Ning Chen (Author), Si-Ming Song (Author), Cui-Cui Zhao (Author), Ya Ruan (Author), Jia-Feng Sha (Author), Qian Liu (Author), Xu-Qin Jiang (Author), Guang-He Fei (Author), Hui-Mei Wu (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itaconate has emerged as a novel anti-inflammatory and antioxidative endogenous metabolite, yet its role in allergic airway inflammation (AAI) and the underlying mechanism remains elusive. Here, the itaconate level in the lung was assessed by High Performance Liquid Chromatography (HPLC), and the ef...