hERG K+ Channels Promote Survival of Irradiated Leukemia Cells

• Main Authors: Daniela Palme (Author), Milan Misovic (Author), Katrin Ganser (Author), Lukas Klumpp (Author), Helmut R. Salih (Author), Daniel Zips (Author), Stephan M. Huber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many tumor cells express highly elevated activities of voltage-gated K+ channels in the plasma membrane which are indispensable for tumor growth. To test for K+ channel function during DNA damage response, we subjected human chronic myeloid leukemia (CML) cells to sub-lethal doses of ionizing radiat...