Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

• Main Authors: Lorenzo Turcano (Author), Theo Battista (Author), Esther Torrente De Haro (Author), Antonino Missineo (Author), Cristina Alli (Author), Giacomo Paonessa (Author), Gianni Colotti (Author), Steven Harper (Author), Annarita Fiorillo (Author), Andrea Ilari (Author), Alberto Bresciani (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive target for the development of novel anti-parasitic...