Conjugation of Amisulpride, an Anti-Psychotic Agent, with 5-Aminosalicylic Acid via an Azo Bond Yields an Orally Active Mutual Prodrug against Rat Colitis

• Autori principali: Wooseong Kim (Autore), Dayoon Kim (Autore), Seongkeun Jeong (Autore), Sanghyun Ju (Autore), Hanju Lee (Autore), Soojin Kim (Autore), Jin-Wook Yoo (Autore), In-Soo Yoon (Autore), Yunjin Jung (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2019-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Amisulpride (ASP), an anti-psychotic agent, is a pharmacologically equivalent to sulpiride (SP). Because SP demonstrates anti-ulcer and anti-colitic activities, ASP with an aniline moiety was azo-coupled to salicylic acid to generate 5-(aminoethanoylsulfamoyl)-<i>N</i>-[(1-ethylpyrrolidi...