Design and Evaluation of An Extended-Release Olmesartan Tablet Using Chitosan/Cyclodextrin Composites

• Main Authors: Makoto Anraku (Author), Ryo Tabuchi (Author), Miwa Goto (Author), Daisuke Iohara (Author), Yasuyuki Mizukai (Author), Yuji Maezaki (Author), Akihiro Michihara (Author), Daisuke Kadowaki (Author), Masaki Otagiri (Author), Fumitoshi Hirayama (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sustained-release olmesartan tablets (OLM) were prepared by the simple, direct compression of composites of anionic sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and cationic spray-dried chitosan (SD-CS), and were evaluated for use as a sustained release preparation for the treatment of hypertension. A...