Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

• Main Authors: Lin-Kong Gong (Author), Xiaodong Yang (Author), Juan Yang (Author), Shu Wu (Author), Yue Chen (Author), Jiang-Tao Zhang (Author), Zhi-Hong Wang (Author), Li-Hua Chen (Author), Chungen Xing (Author), Tong Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ganciclovir (GCV) is a prodrug nucleoside analogue and is clinically used as antiviral drug for the treatment of cytomegalovirus (CMV) and other infections. Based on the potential anti-inflammatory activity of GCV, this study aimed to investigate the therapeutic effects of ganciclovir on dextran sul...