Synthesis and biological evaluation of novel 7-hydroxy-4-phenylchromen-2-one-linked to triazole moieties as potent cytotoxic agents

• المؤلفون الرئيسيون: Chuan-Feng Liu (مؤلف), Qing-Kun Shen (مؤلف), Jia-Jun Li (مؤلف), Yu-Shun Tian (مؤلف), Zheshan Quan (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)-linked 1,2,4-triazoles were synthesised using a click chemistry approach. All derivatives were subjected to 3-(4,5-dimethylthiazol-yl)-diphenyl tetrazolium bromide (MTT) cytotoxicity screening against a panel of six different human cancer ce...