Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

• Main Authors: Jiahui Song (Author), Haining Lv (Author), Beibei Liu (Author), Mingjun Hao (Author), Hugh S. Taylor (Author), Xuchen Zhang (Author), Da Li (Author), Yingqun Huang (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. Methods: Using transient transfection...