Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

• Asıl Yazarlar: Jiahui Song (Yazar), Haining Lv (Yazar), Beibei Liu (Yazar), Mingjun Hao (Yazar), Hugh S. Taylor (Yazar), Xuchen Zhang (Yazar), Da Li (Yazar), Yingqun Huang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. Methods: Using transient transfection...