Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

• Hoofdauteurs: Jiahui Song (Auteur), Haining Lv (Auteur), Beibei Liu (Auteur), Mingjun Hao (Auteur), Hugh S. Taylor (Auteur), Xuchen Zhang (Auteur), Da Li (Auteur), Yingqun Huang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. Methods: Using transient transfection...