Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study

• Main Authors: Mingming Pan (Author), Guihua Wang (Author), Li Zhou (Author), Yan Xu (Author), Li Yao (Author), Chaoqing Wu (Author), Changlin Mei (Author), Zhanzheng Zhao (Author), Dong Sun (Author), Tianjun Guan (Author), Qinkai Chen (Author), Ming Shi (Author), Hui Xu (Author), Weifang Zeng (Author), Fangqiong Li (Author), Rui Yan (Author), Bi-Cheng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptor agonist has been proven to be a safe and effective analgesic and antipruritic drug in both in vitro and in vivo studies. We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-...