RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy

• Главные авторы: Ichiro Yajima (Автор), Mayuko Y. Kumasaka (Автор), Nguyen Dinh Thang (Автор), Yuji Goto (Автор), Kozue Takeda (Автор), Osamu Yamanoshita (Автор), Machiko Iida (Автор), Nobutaka Ohgami (Автор), Haruka Tamura (Автор), Yoshiyuki Kawamoto (Автор), Masashi Kato (Автор)
• Формат: ‌
• Опубликовано: Hindawi Limited, 2012-01-01T00:00:00Z.
• Предметы: article
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Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of me...