RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy

• Main Authors: Ichiro Yajima (Author), Mayuko Y. Kumasaka (Author), Nguyen Dinh Thang (Author), Yuji Goto (Author), Kozue Takeda (Author), Osamu Yamanoshita (Author), Machiko Iida (Author), Nobutaka Ohgami (Author), Haruka Tamura (Author), Yoshiyuki Kawamoto (Author), Masashi Kato (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of me...