Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

• Main Authors: Ivan Liashkovich (Author), Sílvio Terra Stefanello (Author), Reshma Vidyadharan (Author), Günter Haufe (Author), Alexander Erofeev (Author), Peter V. Gorelkin (Author), Vasilii Kolmogorov (Author), Caren Rigon Mizdal (Author), Alexander Dulebo (Author), Etmar Bulk (Author), Ian U. Kouzel (Author), Victor Shahin (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory effects. Herein, we developed and ex...