EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation

• Main Authors: Bixing Ye (Author), Biao Duan (Author), Wenjie Deng (Author), Yueyuan Wang (Author), Yan Chen (Author), Jie Cui (Author), Shixiu Sun (Author), Yujie Zhang (Author), Jun Du (Author), Luo Gu (Author), Lin Lin (Author), Yurong Tang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The aim of this study was to reveal the specific molecular mechanisms by which DENND1A accepts EGF signaling and activates Rab35 in gastric cancer.Methods: The expression of proteins related to DENND1A was examined by western blot analysis. Activation of Rab35 was assessed by GST-pulldown. The...