Polyols Permeability on Caco-2 Cells and Their Effects on Transport of Low-Permeability Drugs

• Main Authors: Damien Truffin (Author), Olaf Häusler (Author), Maryse Martin (Author), Sandrine Cotier (Author), Jerôme Laparre (Author), Manilduth Ramnath (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some pharmaceutical excipients are able to modify intestinal permeability, thus influencing drug absorption and bioavailability. The effect of four polyols (mannitol, maltitol, sorbitol and xylitol) on the permeability of seven active pharmaceutical ingredients (API), representing different BCS clas...