Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves' Ophthalmopathy through the Regulation of FoxO3a Signaling

• Autores principales: Yi-Hsuan Wei (Autor), Shu-Lang Liao (Autor), Chia-Chun Wang (Autor), Sen-Hsu Wang (Autor), Wan-Chun Tang (Autor), Chang-Hao Yang (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2021-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Graves' ophthalmopathy (GO), which is characterized by orbital tissue inflammation, expansion, and fibrosis, is the ocular manifestation in 25% to 50% of patients with Graves' disease. As the pathology of GO is driven by autoimmune inflammation, many proinflammatory cytokines/chemokines, i...