Bioanalytical method development and validation of milnacipran in rat plasma by LCâMS/MS detection and its application to a pharmacokinetic study

• Main Authors: Kanchanamala Kanala (Author), Nagiat T. Hwisa (Author), Babu Rao Chandu (Author), Prakash Katakam (Author), Mukkanti Khagga (Author), B.R. Challa (Author), Bhavyasri Khagga (Author)
• Format: Book
• Published: Elsevier, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple, sensitive and specific liquid chromatographyâtandem mass spectrometry (LCâMS/MS) method was developed for the quantification of milnacipran (MC) in rat plasma by using the liquidâliquid extraction method. Milnacipran-d10 (MCD10) was used as an internal standard (IS). Chromatographic separa...