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miR-199a-3p increases the anti-tumor activity of palbociclib in liver cancer models

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Palbociclib is in early-stage clinical testing in advanced hepatocellular carcinoma (HCC). Here, we investigated whether the anti-tumor activity of palbociclib, which prevents the CDK4/6-mediated phosphorylation of RB1 but simultaneously activates AKT signaling, could be improved by its combination...

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Main Authors: Elisa Callegari (Author), Paola Guerriero (Author), Cristian Bassi (Author), Lucilla D'Abundo (Author), Antonio Frassoldati (Author), Edi Simoni (Author), Laura Astolfi (Author), Enrico Maria Silini (Author), Silvia Sabbioni (Author), Massimo Negrini (Author)
Format: Book
Published: Elsevier, 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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