Preclinical Assessment of Ursolic Acid Loaded into Nanostructured Lipid Carriers in Experimental Visceral Leishmaniasis

• Main Authors: Jéssica Adriana Jesus (Author), Ilza Maria Oliveira Sousa (Author), Thays Nicolli Fragoso da Silva (Author), Aurea Favero Ferreira (Author), Márcia Dalastra Laurenti (Author), Leila Antonangelo (Author), Caroline Silvério Faria (Author), Paulo Cardoso da Costa (Author), Domingos de Carvalho Ferreira (Author), Luiz Felipe Domingues Passero (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ursolic acid, a triterpene produced by plants, displayed leishmanicidal activity in vitro and in vivo; however, the low solubility of this triterpene limits its efficacy. To increase the activity of ursolic acid (UA), this triterpene was entrapped in nanostructured lipid carriers (UA-NLC), physical-...