Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Cytosolic nucleotidases (cNs) catalyze dephosphorylation of nucleoside 5'-monophosphates and thereby contribute to the regulation of nucleotide levels in cells. cNs have also been shown to dephosphorylate several therapeutically relevant nucleotide analogues. cN-IIIB has shown in vitro a distin...

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Main Authors: Dorota Kubacka (Author), Mateusz Kozarski (Author), Marek R. Baranowski (Author), Radoslaw Wojcik (Author), Joanna Panecka-Hofman (Author), Dominika Strzelecka (Author), Jerome Basquin (Author), Jacek Jemielity (Author), Joanna Kowalska (Author)
Format: Book
Published: MDPI AG, 2022-04-01T00:00:00Z.
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