Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

• Päätekijät: Dorota Kubacka (Tekijä), Mateusz Kozarski (Tekijä), Marek R. Baranowski (Tekijä), Radoslaw Wojcik (Tekijä), Joanna Panecka-Hofman (Tekijä), Dominika Strzelecka (Tekijä), Jerome Basquin (Tekijä), Jacek Jemielity (Tekijä), Joanna Kowalska (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Cytosolic nucleotidases (cNs) catalyze dephosphorylation of nucleoside 5'-monophosphates and thereby contribute to the regulation of nucleotide levels in cells. cNs have also been shown to dephosphorylate several therapeutically relevant nucleotide analogues. cN-IIIB has shown in vitro a distin...