The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice

• Main Authors: Dadi Xie (Author), Jinxiu Guo (Author), Ruili Dang (Author), Yanan Li (Author), Qingying Si (Author), Wenxiu Han (Author), Shan Wang (Author), Ning Wei (Author), Junjun Meng (Author), Linlin Wu (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, namely, cardio-, nephro-, hepato-, and neurotoxicity. Prior metabolomic investigati...