Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug‐Drug Interaction

• Main Authors: Tuija Tapaninen (Author), Aleksi M. Olkkola (Author), Aleksi Tornio (Author), Mikko Neuvonen (Author), Erkki Elonen (Author), Pertti J. Neuvonen (Author), Mikko Niemi (Author), Janne T. Backman (Author)
• Format: Book
• Published: Wiley, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole on ibrutinib pharmacokinetics. In a randomized crosso...