Cover Image

Combined <i>In Silico</i> and <i>In Vitro</i> Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications. A key to this approach is selecting the cellular targets against which to identify nove...

Full description

Saved in:

Bibliographic Details
Main Authors:	Saiful Islam (Author), Theodosia Teo (Author), Malika Kumarasiri (Author), Martin Slater (Author), Jennifer H. Martin (Author), Shudong Wang (Author), Richard Head (Author)
Format:	Book
Published:	MDPI AG, 2022-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

<i>Thymus zygis</i> subsp. <i>zygis</i> an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities
by: Amélia M. Silva, et al.
Published: (2020)

Antioxidant and Anti-Proliferative Properties of <i>Hagenia abyssinica</i> Roots and Their Potentially Active Components
by: Minxia Fan, et al.
Published: (2020)

Anti-Proliferative and Genotoxic Activities of the <i>Helichrysum petiolare</i> Hilliard & B.L. Burtt
by: Idowu Jonas Sagbo, et al.
Published: (2020)

In Silico and In Vitro Analysis of Sulforaphane Anti-<i>Candida</i> Activity
by: Bruna L. R. Silva, et al.
Published: (2022)

Chemical Constituents, Anticancer and Anti-Proliferative Potential of <i>Limonium</i> Species: A Systematic Review
by: Naiara Cássia Gancedo, et al.
Published: (2023)

In Vitro Comparison of the Anti-Proliferative Effects of <i>Galenia africana</i> on Human Skin Cell Lines
by: Banele Ndlovu, et al.
Published: (2021)

In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from <i>Variola virus</i>
by: Danielle R. Garcia, et al.
Published: (2021)

Anti-<i>Trypanosoma cruzi</i> Properties of Sesquiterpene Lactones Isolated from <i>Stevia</i> spp.: In Vitro and In Silico Studies
by: Jimena Borgo, et al.
Published: (2023)

Investigation of Antimicrobial and Anti-Inflammatory Efficacy of Newly Synthesized Pyrogallol-Coumarin Hybrids: <i>In Vitro</i> and <i>In Silico</i> Studies
by: Dušica Simijonović, et al.
Published: (2024)

Anti-Inflammatory Principles from the Needles of <i>Pinus taiwanensis</i> Hayata and In Silico Studies of Their Potential Anti-Aging Effects
by: Ping-Chung Kuo, et al.
Published: (2021)

Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and Cultivated <i>Nigella damascena</i> Species Collected in Sicily (Italy)
by: Monica Scognamiglio, et al.
Published: (2024)

Phytochemical Characterization, Antioxidant and Anti-Proliferative Properties of <i>Rubia cordifolia</i> L. Extracts Prepared with Improved Extraction Conditions
by: Ravikiran B. Humbare, et al.
Published: (2022)

Unveiling the Antimicrobial, Anti-Biofilm, and Anti-Quorum-Sensing Potential of <i>Paederia foetida</i> Linn. Leaf Extract against <i>Staphylococcus aureus</i>: An Integrated In Vitro-In Silico Investigation
by: Sirijan Santajit, et al.
Published: (2024)

In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from <i>Ochna rhizomatosa</i> on HIV-1 Integrase and <i>Plasmodium falciparum</i>
by: Angélique Nicolas Messi, et al.
Published: (2022)

Isolation, Identification, Anti-Inflammatory, and In Silico Analysis of New Lignans from the Resin of <i>Ferula sinkiangensis</i>
by: Junchi Wang, et al.
Published: (2023)

In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides from <i>Thalassophryne nattereri</i> Natterin Toxins
by: Gabrielle Lupeti De Cena, et al.
Published: (2022)

Anti-Inflammatory Potential of Daturaolone from <i>Datura innoxia</i> Mill.: In Silico, In Vitro and In Vivo Studies
by: Muhammad Waleed Baig, et al.
Published: (2021)

<i>Annona muricata</i> Leaf as an Anti-Cryptosporidial Agent: An In Silico Molecular Docking Analysis and In Vivo Studies
by: Eman S. El-Wakil, et al.
Published: (2023)

Antioxidant, Anti-Proliferative Activity and Chemical Fingerprinting of <i>Centaurea calcitrapa</i> against Breast Cancer Cells and Molecular Docking of Caspase-3
by: Mourad A. M. Aboul-Soud, et al.
Published: (2022)

In Vitro Antioxidant and In Silico Evaluation of the Anti-β-Lactamase Potential of the Extracts of <i>Cylindrospermum alatosporum</i> NR125682 and <i>Loriellopsis cavenicola</i> NR117881
by: Albert O. Ikhane, et al.
Published: (2024)

Antiproliferative Activity of a New Quinazolin-4(3<i>H</i>)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer
by: Ji Yun Lee, et al.
Published: (2022)

Evaluating Biofilm Inhibitory Potential in Fish Pathogen, <i>Aeromonas hydrophila</i> by Agricultural Waste Extracts and Assessment of Aerolysin Inhibitors Using <i>In Silico</i> Approach
by: Manikandan Arumugam, et al.
Published: (2023)

Above the Invasive and Ornamental Attributes of the Traveler's Palm: An In Vitro and In Silico Insight into the Anti-Oxidant, Anti-Enzymatic, Cytotoxic and Phytochemical Characterization of <i>Ravenala madagascariensis</i>
by: Shanoo Suroowan, et al.
Published: (2023)

Preliminary Investigation of <i>Astragalus arpilobus</i> subsp. <i>hauarensis</i>: LC-MS/MS Chemical Profiling, In Vitro Evaluation of Antioxidant, Anti-Inflammatory Properties, Cytotoxicity, and In Silico Analysis against COX-2
by: Sabrina Lekmine, et al.
Published: (2024)

<i>Achillea fragrantissima</i> (Forssk.) Sch.Bip Flower Dichloromethane Extract Exerts Anti-Proliferative and Pro-Apoptotic Properties in Human Triple-Negative Breast Cancer (MDA-MB-231) Cells: In Vitro and In Silico Studies
by: Nora Alshuail, et al.
Published: (2022)

UHPLC-MS Chemical Fingerprinting and Antioxidant, Enzyme Inhibition, Anti-Inflammatory In Silico and Cytoprotective Activities of <i>Cladonia chlorophaea</i> and <i>C. gracilis</i> (Cladoniaceae) from Antarctica
by: Alfredo Torres-Benítez, et al.
Published: (2022)

Anti-Biofilm and Antibacterial Activities of <i>Cycas media</i> R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches
by: Nashwah G. M. Attallah, et al.
Published: (2022)

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by <i>Scaptotrigona affinis postica</i>: in silico, in vitro, and in vivo Studies
by: Alberto Jorge Oliveira Lopes, et al.
Published: (2020)

Anti-Alzheimer's Potency of Rich Phenylethanoid Glycosides Extract from <i>Marrubium vulgare</i> L.: In Vitro and In Silico Studies
by: Mahmoud Emam, et al.
Published: (2024)

Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2<i>H</i>)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker
by: Mehmet Abdullah Alagöz, et al.
Published: (2021)

Antitumor effects of vitamin B12 <i>in vitro</i>, <i>in vivo</i>, <i>in silico</i>
by: O. A. Gromova, et al.
Published: (2023)

In Silico Study of the Potential Inhibitory Effects on <i>Escherichia coli</i> DNA Gyrase of Some Hypothetical Fluoroquinolone-Tetracycline Hybrids
by: Ioana-Andreea Lungu, et al.
Published: (2024)

The Anti-Virulence Effect of <i>Vismia guianensis</i> against <i>Candida albicans</i> and <i>Candida glabrata</i>
by: Elizangela Pestana Motta, et al.
Published: (2022)

Anti-<i>Helicobacter pylori</i> Biofilm Extracts from <i>Rubus idaeus</i> and <i>Rubus occidentalis</i>
by: Rafał Hałasa, et al.
Published: (2024)

Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from <i>Lycium shawii</i> and <i>Aloe vera</i>: Evidence from In Silico Target Fishing and In Vitro Testing
by: Najeeb Ur Rehman, et al.
Published: (2020)

Anti-Biofilm and Anti-Quorum-Sensing Activity of <i>Inula</i> Extracts: A Strategy for Modulating <i>Chromobacterium violaceum</i> Virulence Factors
by: Petya D. Dimitrova, et al.
Published: (2024)

Design, Synthesis and Biological Assessment of <i>N</i>'-(2-Oxoindolin-3-ylidene)-6-methylimidazo[2,1-<i>b</i>]thiazole-5-carbohydrazides as Potential Anti-Proliferative Agents toward MCF-7 Breast Cancer
by: Najla A. Alshaye, et al.
Published: (2024)

Anti-Inflammatory and Anti-Acne Effects of <i>Hamamelis virginiana</i> Bark in Human Keratinocytes
by: Stefano Piazza, et al.
Published: (2022)

Anti-Tumor and Anti-Inflammatory Activity In Vivo of <i>Apodanthera congestiflora</i> Cogn. (Cucurbitaceae)
by: Geovana F. G. Silvestre, et al.
Published: (2021)

<i>Kalanchoe tomentosa</i>: Phytochemical Profiling, and Evaluation of Its Biological Activities <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i>
by: Jorge L. Mejía-Méndez, et al.
Published: (2024)