Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells

• Main Authors: Peng-Cheng Yu (Author), Di Liu (Author), Zeng-Xiang Han (Author), Fang Liang (Author), Cui-Yun Hao (Author), Yun-Tao Lei (Author), Chang-Run Guo (Author), Wen-Hui Wang (Author), Xing-Hua Li (Author), Xiao-Na Yang (Author), Chang-Zhu Li (Author), Ye Yu (Author), Ying-Zhe Fan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thymopentin (TP5) is an immunomodulatory pentapeptide that has been widely used in malignancy patients with immunodeficiency due to radiotherapy and chemotherapy. Here, we propose that TP5 directly inhibits the stemness of colon cancer cells HCT116 and therefore enhances the cytotoxicity of oxalipla...