The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury

• Autori principali: Frédéric Jaisser (Autore), Xiaojuan Tan (Autore), Shuangshuang Chi (Autore), Jinrong Liu (Autore), Ping Wang (Autore), Mark Bush (Autore), Vincent Benn (Autore), Y. Fred Yang (Autore), Jay Zhang (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The therapeutic indices (TIs) and efficacy of the non-steroidal mineralocorticoid receptor antagonist (MRA) KBP-5074 and steroidal MRA eplerenone were evaluated in a uninephrectomized Sprague Dawley rat model of aldosterone-mediated renal disease. In two parallel studies, rats were placed on a high-...