The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury

• Prif Awduron: Frédéric Jaisser (Awdur), Xiaojuan Tan (Awdur), Shuangshuang Chi (Awdur), Jinrong Liu (Awdur), Ping Wang (Awdur), Mark Bush (Awdur), Vincent Benn (Awdur), Y. Fred Yang (Awdur), Jay Zhang (Awdur)
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• Cyhoeddwyd: Frontiers Media S.A., 2021-06-01T00:00:00Z.
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The therapeutic indices (TIs) and efficacy of the non-steroidal mineralocorticoid receptor antagonist (MRA) KBP-5074 and steroidal MRA eplerenone were evaluated in a uninephrectomized Sprague Dawley rat model of aldosterone-mediated renal disease. In two parallel studies, rats were placed on a high-...