Electrostatic properties of human germlines and biodistribution of small biologics

• Main Authors: Leticia Maria De Souza Cordeiro (Author), Kelley Christine Atkinson (Author), Argin Aivazian (Author), Patrick Frank Joyce (Author), Fang Jia (Author), Alessandro Mascioni (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTOff-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy) can accumulate at clearance organs like kidneys and liver, where they can cause dose-limiting...