The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry

• Main Authors: Akiko Sumi (Author), Udai Nakamura (Author), Masanori Iwase (Author), Hiroki Fujii (Author), Toshiaki Ohkuma (Author), Hitoshi Ide (Author), Tamaki Jodai-Kitamura (Author), Yuji Komorita (Author), Masahito Yoshinari (Author), Yoichiro Hirakawa (Author), Atsushi Hirano (Author), Michiaki Kubo (Author), Takanari Kitazono (Author)
• Format: Book
• Published: BMC, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. Methods Adult Japanese type 2 diabe...