Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids

• Main Authors: Emily L. Miedzybrodzka (Author), Rachel E. Foreman (Author), Van B. Lu (Author), Amy L. George (Author), Christopher A. Smith (Author), Pierre Larraufie (Author), Richard G. Kay (Author), Deborah A. Goldspink (Author), Frank Reimann (Author), Fiona M. Gribble (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying, and hunger initiation. In vivo motilin release is stimulated by fats, bile, and duodenal acidification but the underlying molecular mechanisms of motilin secretion remain poorly u...